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Topologies of a Substrate Protein Bound to the Chaperonin GroEL

The chaperonin GroEL assists polypeptide folding through sequential steps of binding nonnative protein in the central cavity of an open ring, via hydrophobic surfaces of its apical domains, followed by encapsulation in a hydrophilic cavity. To examine the binding state, we have classified a large da...

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Detalles Bibliográficos
Main Authors: Elad, Nadav, Farr, George W., Clare, Daniel K., Orlova, Elena V., Horwich, Arthur L., Saibil, Helen R.
Formato: Artigo
Idioma:Inglês
Publicado: Cell Press 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885994/
https://ncbi.nlm.nih.gov/pubmed/17499047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.04.004
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