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Topologies of a Substrate Protein Bound to the Chaperonin GroEL

The chaperonin GroEL assists polypeptide folding through sequential steps of binding nonnative protein in the central cavity of an open ring, via hydrophobic surfaces of its apical domains, followed by encapsulation in a hydrophilic cavity. To examine the binding state, we have classified a large da...

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Autors principals: Elad, Nadav, Farr, George W., Clare, Daniel K., Orlova, Elena V., Horwich, Arthur L., Saibil, Helen R.
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885994/
https://ncbi.nlm.nih.gov/pubmed/17499047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.04.004
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