The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule

IRE1 couples endoplasmic reticulum unfolded protein load to RNA cleavage events that culminate in the sequence-specific splicing of the Xbp1 mRNA and in the regulated degradation of diverse membrane-bound mRNAs. We report on the identification of a small molecule inhibitor that attains its selectivi...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Cross, Benedict C. S., Bond, Peter J., Sadowski, Pawel G., Jha, Babal Kant, Zak, Jaroslav, Goodman, Jonathan M., Silverman, Robert H., Neubert, Thomas A., Baxendale, Ian R., Ron, David, Harding, Heather P.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2012
Предметы:
PNAS Plus
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326519/
https://ncbi.nlm.nih.gov/pubmed/22315414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1115623109
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы