The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule

IRE1 couples endoplasmic reticulum unfolded protein load to RNA cleavage events that culminate in the sequence-specific splicing of the Xbp1 mRNA and in the regulated degradation of diverse membrane-bound mRNAs. We report on the identification of a small molecule inhibitor that attains its selectivi...

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Detalhes bibliográficos
Main Authors: Cross, Benedict C. S., Bond, Peter J., Sadowski, Pawel G., Jha, Babal Kant, Zak, Jaroslav, Goodman, Jonathan M., Silverman, Robert H., Neubert, Thomas A., Baxendale, Ian R., Ron, David, Harding, Heather P.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326519/
https://ncbi.nlm.nih.gov/pubmed/22315414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1115623109
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