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Structural and mechanistic insights into the activation of Stromal interaction molecule 1 (STIM1)

Calcium influx through the Ca(2+) release-activated Ca(2+) (CRAC) channel is an essential process in many types of cells. Upon store depletion, the calcium sensor in the endoplasmic reticulum, STIM1, activates Orai1, a CRAC channel in the plasma membrane. We have determined the structures of SOAR fr...

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Autors principals: Yang, Xue, Jin, Hao, Cai, Xiangyu, Li, Siwei, Shen, Yuequan
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326449/
https://ncbi.nlm.nih.gov/pubmed/22451904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1118947109
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