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Structural and mechanistic insights into the activation of Stromal interaction molecule 1 (STIM1)
Calcium influx through the Ca(2+) release-activated Ca(2+) (CRAC) channel is an essential process in many types of cells. Upon store depletion, the calcium sensor in the endoplasmic reticulum, STIM1, activates Orai1, a CRAC channel in the plasma membrane. We have determined the structures of SOAR fr...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3326449/ https://ncbi.nlm.nih.gov/pubmed/22451904 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1118947109 |
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