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Benzo[e]pyridoindoles, novel inhibitors of the aurora kinases

Aurora kinases are serine/threonine protein kinases that are involved in cancer development and are important targets for cancer therapy. By high throughput screening of a chemical library we found that benzo[e]pyridoindole derivatives inhibited Aurora kinase. The most potent compound (compound 1) w...

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Main Authors: Hoang, Thi My-Nhung, Favier, Bertrand, Valette, Annie, Barette, Caroline, Nguyen, Chi Hung, Lafanechère, Laurence, Grierson, David S., Dimitrov, Stéfan, Molla, Annie
פורמט: Artigo
שפה:Inglês
יצא לאור: Landes Bioscience 2009
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3325905/
https://ncbi.nlm.nih.gov/pubmed/19221479
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