Discovery of benzo[e]pyridoindolones as kinase inhibitors that disrupt mitosis exit while erasing AMPK-Thr172 phosphorylation on the spindle

Aurora kinases play an essential role in mitotic progression and are attractive targets in cancer therapy. The first generation of benzo[e]pyridoindole exhibited powerful aurora kinase inhibition but their low solubility limited further development. Grafting a pyperidine-ethoxy group gives rise to a...

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Vydáno v:Oncotarget
Hlavní autoři: Le, Ly-Thuy-Tram, Couvet, Morgane, Favier, Bertrand, Coll, Jean-Luc, Nguyen, Chi-Hung, Molla, Annie
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673153/
https://ncbi.nlm.nih.gov/pubmed/26247630
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