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In Vitro High Throughput Screening, What Next? Lessons from the Screening for Aurora Kinase Inhibitors
Based on in vitro assays, we performed a High Throughput Screening (HTS) to identify kinase inhibitors among 10,000 small chemical compounds. In this didactic paper, we describe step-by-step the approach to validate the hits as well as the major pitfalls encountered in the development of active mole...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
MDPI
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4009756/ https://ncbi.nlm.nih.gov/pubmed/24833340 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biology3010167 |
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