Complement Component C3 and Complement Receptor Type 3 Contribute to the Phagocytosis and Clearance of Fibrillar Aβ by Microglia

Complement components and their receptors are found within and around Aβ cerebral plaques in Alzheimer’s disease (AD). Microglia defend against pathogens through phagocytosis via complement component C3 and/or engagement of C3 cleavage product iC3b with complement receptor type 3 (CR3, Mac-1). Here...

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Hlavní autoři: Fu, Hongjun, Liu, Bin, Frost, Jeffrey L., Hong, Soyon, Jin, Ming, Ostaszewski, Beth, Shankar, Ganesh M., Costantino, Isabel M., Carroll, Michael C., Mayadas, Tanya N., Lemere, Cynthia A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3325361/
https://ncbi.nlm.nih.gov/pubmed/22438044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.22331
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