Complement and Microglia Mediate Early Synapse Loss in Alzheimer Mouse Models

Synapse loss in Alzheimer's disease (AD) correlates with cognitive decline. Involvement of microglia and complement in AD has been attributed to neuroinflammation, prominent late in disease. Here we show in mouse models that complement and microglia mediate synaptic loss early in AD. C1q, the i...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Hong, Soyon, Beja-Glasser, Victoria F, Nfonoyim, Bianca M, Frouin, Arnaud, Li, Shaomin, Ramakrishnan, Saranya, Merry, Katherine M, Shi, Qiaoqiao, Rosenthal, Arnon, Barres, Ben A, Lemere, Cynthia A, Selkoe, Dennis J, Stevens, Beth
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5094372/
https://ncbi.nlm.nih.gov/pubmed/27033548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad8373
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