Complement and Microglia Mediate Early Synapse Loss in Alzheimer Mouse Models

Synapse loss in Alzheimer's disease (AD) correlates with cognitive decline. Involvement of microglia and complement in AD has been attributed to neuroinflammation, prominent late in disease. Here we show in mouse models that complement and microglia mediate synaptic loss early in AD. C1q, the i...

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Pubblicato in:Science
Autori principali: Hong, Soyon, Beja-Glasser, Victoria F, Nfonoyim, Bianca M, Frouin, Arnaud, Li, Shaomin, Ramakrishnan, Saranya, Merry, Katherine M, Shi, Qiaoqiao, Rosenthal, Arnon, Barres, Ben A, Lemere, Cynthia A, Selkoe, Dennis J, Stevens, Beth
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5094372/
https://ncbi.nlm.nih.gov/pubmed/27033548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad8373
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