CD47 protects synapses from excess microglia-mediated pruning during development

Microglia regulate synaptic circuit remodeling and phagocytose synaptic material in the healthy brain; however, the mechanisms directing microglia to engulf specific synapses and avoid others remain unknown. Here, we demonstrate that an innate immune signaling pathway protects synapses from inapprop...

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Gepubliceerd in:Neuron
Hoofdauteurs: Lehrman, Emily K., Wilton, Daniel K., Litvina, Elizabeth Y., Welsh, Christina A., Chang, Stephen T., Frouin, Arnaud, Walker, Alec J., Heller, Molly D., Umemori, Hisashi, Chen, Chinfei, Stevens, Beth
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6314207/
https://ncbi.nlm.nih.gov/pubmed/30308165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2018.09.017
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