Complement and Microglia Mediate Early Synapse Loss in Alzheimer Mouse Models

Synapse loss in Alzheimer's disease (AD) correlates with cognitive decline. Involvement of microglia and complement in AD has been attributed to neuroinflammation, prominent late in disease. Here we show in mouse models that complement and microglia mediate synaptic loss early in AD. C1q, the i...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Science
Päätekijät: Hong, Soyon, Beja-Glasser, Victoria F, Nfonoyim, Bianca M, Frouin, Arnaud, Li, Shaomin, Ramakrishnan, Saranya, Merry, Katherine M, Shi, Qiaoqiao, Rosenthal, Arnon, Barres, Ben A, Lemere, Cynthia A, Selkoe, Dennis J, Stevens, Beth
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2016
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5094372/
https://ncbi.nlm.nih.gov/pubmed/27033548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad8373
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