Memory Impairment in Transgenic Alzheimer Mice Requires Cellular Prion Protein

Soluble oligomers of the amyloid-β (Aβ) peptide are thought to play a key role in the pathophysiology of Alzheimer's disease (AD). Recently, we reported that synthetic Aβ oligomers bind to cellular prion protein (PrP(C)) and that this interaction is required for suppression of synaptic plastici...

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Bibliografiset tiedot
Päätekijät: Gimbel, David A., Nygaard, Haakon B., Coffey, Erin E., Gunther, Erik C., Laurén, Juha, Gimbel, Zachary A., Strittmatter, Stephen M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Society for Neuroscience 2010
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Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323924/
https://ncbi.nlm.nih.gov/pubmed/20445063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0395-10.2010
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