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Rescue of Transgenic Alzheimer’s Pathophysiology by Polymeric Cellular Prion Protein Antagonists
Cellular prion protein (PrP(C)) binds the scrapie conformation of PrP (PrP(Sc)) and oligomeric β-amyloid peptide (Aβo) to mediate transmissible spongiform encephalopathy (TSE) and Alzheimer’s disease (AD), respectively. We conducted cellular and biochemical screens for compounds blocking PrP(C) inte...
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| Published in: | Cell Rep |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2019
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6358723/ https://ncbi.nlm.nih.gov/pubmed/30605671 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.12.021 |
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