Rescue of Transgenic Alzheimer’s Pathophysiology by Polymeric Cellular Prion Protein Antagonists

Cellular prion protein (PrP(C)) binds the scrapie conformation of PrP (PrP(Sc)) and oligomeric β-amyloid peptide (Aβo) to mediate transmissible spongiform encephalopathy (TSE) and Alzheimer’s disease (AD), respectively. We conducted cellular and biochemical screens for compounds blocking PrP(C) inte...

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Publicat a:Cell Rep
Autors principals: Gunther, Erik C., Smith, Levi M., Kostylev, Mikhail A., Cox, Timothy O., Kaufman, Adam C., Lee, Suho, Folta-Stogniew, Ewa, Maynard, George D., Um, Ji Won, Stagi, Massimiliano, Heiss, Jacqueline K., Stoner, Austin, Noble, Geoff P., Takahashi, Hideyuki, Haas, Laura T., Schneekloth, John S., Merkel, Janie, Teran, Christopher, Naderi, Zaha K., Supattapone, Surachai, Strittmatter, Stephen M.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6358723/
https://ncbi.nlm.nih.gov/pubmed/30605671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.12.021
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