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Rescue of Transgenic Alzheimer’s Pathophysiology by Polymeric Cellular Prion Protein Antagonists

Cellular prion protein (PrP(C)) binds the scrapie conformation of PrP (PrP(Sc)) and oligomeric β-amyloid peptide (Aβo) to mediate transmissible spongiform encephalopathy (TSE) and Alzheimer’s disease (AD), respectively. We conducted cellular and biochemical screens for compounds blocking PrP(C) inte...

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Bibliografische gegevens
Gepubliceerd in:Cell Rep
Hoofdauteurs: Gunther, Erik C., Smith, Levi M., Kostylev, Mikhail A., Cox, Timothy O., Kaufman, Adam C., Lee, Suho, Folta-Stogniew, Ewa, Maynard, George D., Um, Ji Won, Stagi, Massimiliano, Heiss, Jacqueline K., Stoner, Austin, Noble, Geoff P., Takahashi, Hideyuki, Haas, Laura T., Schneekloth, John S., Merkel, Janie, Teran, Christopher, Naderi, Zaha K., Supattapone, Surachai, Strittmatter, Stephen M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6358723/
https://ncbi.nlm.nih.gov/pubmed/30605671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.12.021
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