Rescue of Transgenic Alzheimer’s Pathophysiology by Polymeric Cellular Prion Protein Antagonists

Cellular prion protein (PrP(C)) binds the scrapie conformation of PrP (PrP(Sc)) and oligomeric β-amyloid peptide (Aβo) to mediate transmissible spongiform encephalopathy (TSE) and Alzheimer’s disease (AD), respectively. We conducted cellular and biochemical screens for compounds blocking PrP(C) inte...

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Published in:Cell Rep
Main Authors: Gunther, Erik C., Smith, Levi M., Kostylev, Mikhail A., Cox, Timothy O., Kaufman, Adam C., Lee, Suho, Folta-Stogniew, Ewa, Maynard, George D., Um, Ji Won, Stagi, Massimiliano, Heiss, Jacqueline K., Stoner, Austin, Noble, Geoff P., Takahashi, Hideyuki, Haas, Laura T., Schneekloth, John S., Merkel, Janie, Teran, Christopher, Naderi, Zaha K., Supattapone, Surachai, Strittmatter, Stephen M.
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6358723/
https://ncbi.nlm.nih.gov/pubmed/30605671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.12.021
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