The Energetic Basis Underpinning T-cell Receptor Recognition of a Super-bulged Peptide Bound to a Major Histocompatibility Complex Class I Molecule

Although the major histocompatibility complex class I (MHC-I) molecules typically bind short peptide (p) fragments (8–10 amino acids in length), longer, “bulged” peptides are often be presented by MHC-I. Such bulged pMHC-I complexes represent challenges for T-cell receptor (TCR) ligation, although t...

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Bibliographic Details
Main Authors: Liu, Yu Chih, Chen, Zhenjun, Burrows, Scott R., Purcell, Anthony W., McCluskey, James, Rossjohn, Jamie, Gras, Stephanie
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3320977/
https://ncbi.nlm.nih.gov/pubmed/22343629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.344689
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