Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability

αβ T cell receptors (TCRs) are genetically restricted to corecognize peptide antigens bound to self-major histocompatibility complex (pMHC) molecules; however, the basis for this MHC specificity remains unclear. Despite the current dogma, evaluation of the TCR–pMHC-I structural database shows that t...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Burrows, Scott R., Chen, Zhenjun, Archbold, Julia K., Tynan, Fleur E., Beddoe, Travis, Kjer-Nielsen, Lars, Miles, John J., Khanna, Rajiv, Moss, Denis J., Liu, Yu Chih, Gras, Stephanie, Kostenko, Lyudmila, Brennan, Rebekah M., Clements, Craig S., Brooks, Andrew G., Purcell, Anthony W., McCluskey, James, Rossjohn, Jamie
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2010
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890827/
https://ncbi.nlm.nih.gov/pubmed/20483993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1004926107
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