Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability

αβ T cell receptors (TCRs) are genetically restricted to corecognize peptide antigens bound to self-major histocompatibility complex (pMHC) molecules; however, the basis for this MHC specificity remains unclear. Despite the current dogma, evaluation of the TCR–pMHC-I structural database shows that t...

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Detalhes bibliográficos
Main Authors: Burrows, Scott R., Chen, Zhenjun, Archbold, Julia K., Tynan, Fleur E., Beddoe, Travis, Kjer-Nielsen, Lars, Miles, John J., Khanna, Rajiv, Moss, Denis J., Liu, Yu Chih, Gras, Stephanie, Kostenko, Lyudmila, Brennan, Rebekah M., Clements, Craig S., Brooks, Andrew G., Purcell, Anthony W., McCluskey, James, Rossjohn, Jamie
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890827/
https://ncbi.nlm.nih.gov/pubmed/20483993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1004926107
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