Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability

αβ T cell receptors (TCRs) are genetically restricted to corecognize peptide antigens bound to self-major histocompatibility complex (pMHC) molecules; however, the basis for this MHC specificity remains unclear. Despite the current dogma, evaluation of the TCR–pMHC-I structural database shows that t...

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Detalles Bibliográficos
Main Authors: Burrows, Scott R., Chen, Zhenjun, Archbold, Julia K., Tynan, Fleur E., Beddoe, Travis, Kjer-Nielsen, Lars, Miles, John J., Khanna, Rajiv, Moss, Denis J., Liu, Yu Chih, Gras, Stephanie, Kostenko, Lyudmila, Brennan, Rebekah M., Clements, Craig S., Brooks, Andrew G., Purcell, Anthony W., McCluskey, James, Rossjohn, Jamie
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890827/
https://ncbi.nlm.nih.gov/pubmed/20483993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1004926107
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