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The binding conformation of Taxol in β-tubulin: A model based on electron crystallographic density

The chemotherapeutic drug Taxol is known to interact within a specific site on β-tubulin. Although the general location of the site has been defined by photoaffinity labeling and electron crystallography, the original data were insufficient to make an absolute determination of the bound conformation...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Snyder, James P., Nettles, James H., Cornett, Ben, Downing, Kenneth H., Nogales, Eva
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2001
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC33206/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11309480/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.051309398
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