Taxol acts differently on different tubulin isotypes
Abstract Taxol is a small molecule effector that allosterically locks tubulin into the microtubule lattice. We show here that taxol has different effects on different single-isotype microtubule lattices. Using in vitro reconstitution, we demonstrate that single-isotype α1β4 GDP-tubulin lattices are...
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| Principais autores: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Portfolio
2023-09-01
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| Serier: | Communications Biology |
| Online adgang: | https://doi.org/10.1038/s42003-023-05306-y |
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