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Isolation of a taxol-resistant Chinese hamster ovary cell mutant that has an alteration in alpha-tubulin.

Taxol is a plant alkaloid that has antimitotic activity and appears to stabilize microtubules [Schiff, P. B., Fant, J. & Horwitz, S. B. (1979) Nature (London) 277, 665-667]. Taxol-resistant cells were selected from a population of UV-mutagen-treated Chinese hamster ovary cells by a single-step p...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Cabral, F, Abraham, I, Gottesman, M M
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 1981
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC319795/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6117076/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.7.4388
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