The binding conformation of Taxol in β-tubulin: A model based on electron crystallographic density

The chemotherapeutic drug Taxol is known to interact within a specific site on β-tubulin. Although the general location of the site has been defined by photoaffinity labeling and electron crystallography, the original data were insufficient to make an absolute determination of the bound conformation...

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Cyhoeddwyd yn:	Proc Natl Acad Sci U S A
Prif Awduron:	Snyder, James P., Nettles, James H., Cornett, Ben, Downing, Kenneth H., Nogales, Eva
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	National Academy of Sciences 2001
Pynciau:	Biological Sciences
Mynediad Ar-lein:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC33206/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11309480/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.051309398
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