Talin Contains A C-Terminal Calpain2 Cleavage Site Important In Focal Adhesion Dynamics

Talin is a large (∼2540 residues) dimeric adaptor protein that associates with the integrin family of cell adhesion molecules in cell-extracellular matrix junctions (focal adhesions; FAs), where it both activates integrins and couples them to the actin cytoskeleton. Calpain2-mediated cleavage of tal...

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Bibliographic Details
Main Authors: Bate, Neil, Gingras, Alexandre R., Bachir, Alexia, Horwitz, Rick, Ye, Feng, Patel, Bipin, Goult, Benjamin T., Critchley, David R.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3319578/
https://ncbi.nlm.nih.gov/pubmed/22496808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034461
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