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Structural model and functional significance of pH-dependent talin–actin binding for focal adhesion remodeling
Actin filament binding by the focal adhesion (FA)-associated protein talin stabilizes cell-substrate adhesions and is thought to be rate-limiting in cell migration. Although F-actin binding by talin is known to be pH-sensitive in vitro, with lower affinity at higher pH, the functional significance o...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2532973/ https://ncbi.nlm.nih.gov/pubmed/18780792 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805163105 |
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