pH sensing by FAK-His58 regulates focal adhesion remodeling

Intracellular pH (pHi) dynamics regulates diverse cellular processes, including remodeling of focal adhesions. We now report that focal adhesion kinase (FAK), a key regulator of focal adhesion remodeling, is a pH sensor responding to physiological changes in pH. The initial step in FAK activation is...

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Detalhes bibliográficos
Main Authors: Choi, Chang-Hoon, Webb, Bradley A., Chimenti, Michael S., Jacobson, Matthew P., Barber, Diane L.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3776353/
https://ncbi.nlm.nih.gov/pubmed/24043700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201302131
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