pH sensing by FAK-His58 regulates focal adhesion remodeling

Intracellular pH (pHi) dynamics regulates diverse cellular processes, including remodeling of focal adhesions. We now report that focal adhesion kinase (FAK), a key regulator of focal adhesion remodeling, is a pH sensor responding to physiological changes in pH. The initial step in FAK activation is...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Choi, Chang-Hoon, Webb, Bradley A., Chimenti, Michael S., Jacobson, Matthew P., Barber, Diane L.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Rockefeller University Press 2013
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3776353/
https://ncbi.nlm.nih.gov/pubmed/24043700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201302131
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