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Folding and activity of mutant cystathionine β-synthase depends on the position and nature of the purification tag: Characterization of the R266K CBS mutant
Cystathionine beta-synthase (CBS), a heme-containing PLP-dependent enzyme, catalyzes the condensation of serine and homocysteine to yield cystathionine. Missense mutations in CBS, the most common cause of homocystinuria, often result in misfolded proteins. Arginine 266, where the pathogenic missense...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3319291/ https://ncbi.nlm.nih.gov/pubmed/22333527 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pep.2012.01.019 |
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