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Conformational properties of nine purified cystathionine beta-synthase mutants
Protein misfolding due to missense mutations is a common pathogenic mechanism in cystathionine beta-synthase (CBS) deficiency. In our previous studies, we have successfully expressed, purified and characterized nine CBS mutant enzymes containing the following patient mutations: P49L, P78R, A114V, R1...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3384745/ https://ncbi.nlm.nih.gov/pubmed/22612060 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300435e |
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