Rescue of Cystathionine β-Synthase (CBS) Mutants with Chemical Chaperones: PURIFICATION AND CHARACTERIZATION OF EIGHT CBS MUTANT ENZYMES

Missense mutations represent the most common cause of many genetic diseases including cystathionine β-synthase (CBS) deficiency. Many of these mutations result in misfolded proteins, which lack biological function. The presence of chemical chaperones can sometimes alleviate or even restore protein f...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Majtan, Tomas, Liu, Lu, Carpenter, John F., Kraus, Jan P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
Soggetti:
Protein Structure and Folding
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2871454/
https://ncbi.nlm.nih.gov/pubmed/20308073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.107722
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi