Identification of Intersubunit Domain Interactions within Eukaryotic Initiation Factor (eIF) 2B, the Nucleotide Exchange Factor for Translation Initiation

In eukaryotic translation initiation, eIF2B is the guanine nucleotide exchange factor (GEF) required for reactivation of the G protein eIF2 between rounds of protein synthesis initiation. eIF2B is unusually complex with five subunits (α–ϵ) necessary for GEF activity and its control by phosphorylatio...

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Hlavní autoři: Reid, Peter J., Mohammad-Qureshi, Sarah S., Pavitt, Graham D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Protein Synthesis and Degradation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318697/
https://ncbi.nlm.nih.gov/pubmed/22238343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.331645
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