Identification of Intersubunit Domain Interactions within Eukaryotic Initiation Factor (eIF) 2B, the Nucleotide Exchange Factor for Translation Initiation

In eukaryotic translation initiation, eIF2B is the guanine nucleotide exchange factor (GEF) required for reactivation of the G protein eIF2 between rounds of protein synthesis initiation. eIF2B is unusually complex with five subunits (α–ϵ) necessary for GEF activity and its control by phosphorylatio...

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Bibliografiska uppgifter
Huvudupphovsmän: Reid, Peter J., Mohammad-Qureshi, Sarah S., Pavitt, Graham D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2012
Ämnen:
Protein Synthesis and Degradation
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318697/
https://ncbi.nlm.nih.gov/pubmed/22238343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.331645
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