An eIF5/eIF2 complex antagonizes guanine nucleotide exchange by eIF2B during translation initiation

Eitemau Tebyg

• eIF2B promotes eIF5 dissociation from eIF2•GDP to facilitate guanine nucleotide exchange for translation initiation
  gan: Jennings, Martin D., et al.
  Cyhoeddwyd: (2013)
• The eukaryotic initiation factor (eIF) 5 HEAT domain mediates multifactor assembly and scanning with distinct interfaces to eIF1, eIF2, eIF3, and eIF4G
  gan: Yamamoto, Yasufumi, et al.
  Cyhoeddwyd: (2005)
• eIF2 independently binds two distinct eIF2B subcomplexes that catalyze and regulate guanine–nucleotide exchange
  gan: Pavitt, Graham D., et al.
  Cyhoeddwyd: (1998)
• Homologous segments in three subunits of the guanine nucleotide exchange factor eIF2B mediate translational regulation by phosphorylation of eIF2.
  gan: Pavitt, G D, et al.
  Cyhoeddwyd: (1997)
• Critical Contacts between the Eukaryotic Initiation Factor 2B (eIF2B) Catalytic Domain and both eIF2β and -2γ Mediate Guanine Nucleotide Exchange
  gan: Mohammad-Qureshi, Sarah S., et al.
  Cyhoeddwyd: (2007)