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An eIF5/eIF2 complex antagonizes guanine nucleotide exchange by eIF2B during translation initiation
In eukaryotic translation initiation, the eIF2·GTP/Met-tRNA(i)(Met) ternary complex (TC) binds the eIF3/eIF1/eIF5 complex to form the multifactor complex (MFC), whereas eIF2·GDP binds the pentameric factor eIF2B for guanine nucleotide exchange. eIF5 and the eIF2Bɛ catalytic subunit possess a conserv...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2006
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1589998/ https://ncbi.nlm.nih.gov/pubmed/16990799 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601339 |
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