An eIF5/eIF2 complex antagonizes guanine nucleotide exchange by eIF2B during translation initiation

In eukaryotic translation initiation, the eIF2·GTP/Met-tRNA(i)(Met) ternary complex (TC) binds the eIF3/eIF1/eIF5 complex to form the multifactor complex (MFC), whereas eIF2·GDP binds the pentameric factor eIF2B for guanine nucleotide exchange. eIF5 and the eIF2Bɛ catalytic subunit possess a conserv...

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Main Authors: Singh, Chingakham Ranjit, Lee, Bumjun, Udagawa, Tsuyoshi, Mohammad-Qureshi, Sarah S, Yamamoto, Yasufumi, Pavitt, Graham D, Asano, Katsura
Formato: Artigo
Idioma:Inglês
Publicado: 2006
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1589998/
https://ncbi.nlm.nih.gov/pubmed/16990799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601339
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