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Critical Contacts between the Eukaryotic Initiation Factor 2B (eIF2B) Catalytic Domain and both eIF2β and -2γ Mediate Guanine Nucleotide Exchange

Diverse guanine nucleotide exchange factors (GEFs) regulate the activity of GTP binding proteins. One of the most complicated pairs is eukaryotic initiation factor 2B (eIF2B) and eIF2, which function during protein synthesis initiation in eukaryotes. We have mutated conserved surface residues within...

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Bibliografske podrobnosti
Main Authors: Mohammad-Qureshi, Sarah S., Haddad, Raphaël, Hemingway, Elizabeth J., Richardson, Jonathan P., Pavitt, Graham D.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1951959/
https://ncbi.nlm.nih.gov/pubmed/17526738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00495-07
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