eIF2B promotes eIF5 dissociation from eIF2•GDP to facilitate guanine nucleotide exchange for translation initiation

Protein synthesis factor eIF2 delivers initiator tRNA to the ribosome. Two proteins regulate its G-protein cycle: eIF5 has both GTPase-accelerating protein (GAP) and GDP dissociation inhibitor (GDI) functions, and eIF2B is the guanine nucleotide exchange factor (GEF). In this study, we used protein–...

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Detalhes bibliográficos
Main Authors: Jennings, Martin D., Zhou, Yu, Mohammad-Qureshi, Sarah S., Bennett, David, Pavitt, Graham D.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2013
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3877758/
https://ncbi.nlm.nih.gov/pubmed/24352424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.231514.113
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