eIF2β is critical for eIF5-mediated GDP-dissociation inhibitor activity and translational control

In protein synthesis translation factor eIF2 binds initiator tRNA to ribosomes and facilitates start codon selection. eIF2 GDP/GTP status is regulated by eIF5 (GAP and GDI functions) and eIF2B (GEF and GDF activities), while eIF2α phosphorylation in response to diverse signals is a major point of tr...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Autores principales: Jennings, Martin D., Kershaw, Christopher J., White, Christopher, Hoyle, Danielle, Richardson, Jonathan P., Costello, Joseph L., Donaldson, Ian J., Zhou, Yu, Pavitt, Graham D.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2016
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5175340/
https://ncbi.nlm.nih.gov/pubmed/27458202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw657
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