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Azole Resistance by Loss of Function of the Sterol Δ(5,6)-Desaturase Gene (ERG3) in Candida albicans Does Not Necessarily Decrease Virulence
The inactivation of ERG3, a gene encoding sterol Δ(5,6)-desaturase (essential for ergosterol biosynthesis), is a known mechanism of in vitro resistance to azole antifungal drugs in the human pathogen Candida albicans. ERG3 inactivation typically results in loss of filamentation and attenuated virule...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3318373/ https://ncbi.nlm.nih.gov/pubmed/22252807 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05720-11 |
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