Inactivation of Sterol Δ(5,6)-Desaturase Attenuates Virulence in Candida albicans

Two clinical Candida albicans isolates that exhibited high-level resistance to azoles and modest decreases in susceptibility to amphotericin B were cultured from unrelated patients. Both isolates harbored homozygous nonsense mutations in ERG3, which encodes an enzyme, sterol Δ(5,6)-desaturase, invol...

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Autores principales: Chau, Andrew S., Gurnani, Maya, Hawkinson, Robyn, Laverdiere, Michel, Cacciapuoti, Anthony, McNicholas, Paul M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2005
Materias:
Mechanisms of Resistance
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1195422/
https://ncbi.nlm.nih.gov/pubmed/16127034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.9.3646-3651.2005
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