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Loss of C-5 Sterol Desaturase Activity in Candida albicans: Azole Resistance or Merely Trailing Growth?

Increased expression of drug efflux pumps and changes in the target enzyme Erg11p are known to contribute to azole resistance in Candida albicans, one of the most prevalent fungal pathogens. Mutations that inactivate ERG3, which encodes sterol Δ(5,6)-desaturase, also confer in vitro azole resistance...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Luna-Tapia, Arturo, Butts, Arielle, Palmer, Glen E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325228/
https://ncbi.nlm.nih.gov/pubmed/30323044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01337-18
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