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Endosomal Trafficking Defects Can Induce Calcium-Dependent Azole Tolerance in Candida albicans

The azole antifungals arrest fungal growth through inhibition of ergosterol biosynthesis. We recently reported that a Candida albicans vps21Δ/Δ mutant, deficient in membrane trafficking through the late endosome/prevacuolar compartment (PVC), continues to grow in the presence of the azoles despite t...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Luna-Tapia, Arturo, Tournu, Hélène, Peters, Tracy L., Palmer, Glen E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5118996/
https://ncbi.nlm.nih.gov/pubmed/27645241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01034-16
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