Naturally variant autosomal and sex-linked loci determine the severity of iron overload in β(2)-microglobulin-deficient mice

Hereditary hemochromatosis (HH) is a common chronic human genetic disorder whose hallmark is systemic iron overload. Homozygosity for a mutation in the MHC class I heavy chain paralogue gene HFE has been found to be a primary cause of HH. However, many individuals homozygous for the defective allele...

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Detalles Bibliográficos
Main Authors: Sproule, Thomas J., Jazwinska, Elizabeth C., Britton, Robert S., Bacon, Bruce R., Fleming, Robert E., Sly, William S., Roopenian, Derry C.
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC33182/
https://ncbi.nlm.nih.gov/pubmed/11309500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.091088998
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