Internalization and Down-Regulation of the ALK Receptor in Neuroblastoma Cell Lines upon Monoclonal Antibodies Treatment

Recently, activating mutations of the full length ALK receptor, with two hot spots at positions F1174 and R1275, have been characterized in sporadic cases of neuroblastoma. Here, we report similar basal patterns of ALK phosphorylation between the neuroblastoma IMR-32 cell line, which expresses only...

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Main Authors: Mazot, Pierre, Cazes, Alex, Dingli, Florent, Degoutin, Joffrey, Irinopoulou, Théano, Boutterin, Marie-Claude, Lombard, Bérangère, Loew, Damarys, Hallberg, Bengt, Palmer, Ruth Helen, Delattre, Olivier, Janoueix-Lerosey, Isabelle, Vigny, Marc
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3316580/
https://ncbi.nlm.nih.gov/pubmed/22479414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033581
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