Internalization and Down-Regulation of the ALK Receptor in Neuroblastoma Cell Lines upon Monoclonal Antibodies Treatment

Recently, activating mutations of the full length ALK receptor, with two hot spots at positions F1174 and R1275, have been characterized in sporadic cases of neuroblastoma. Here, we report similar basal patterns of ALK phosphorylation between the neuroblastoma IMR-32 cell line, which expresses only...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Mazot, Pierre, Cazes, Alex, Dingli, Florent, Degoutin, Joffrey, Irinopoulou, Théano, Boutterin, Marie-Claude, Lombard, Bérangère, Loew, Damarys, Hallberg, Bengt, Palmer, Ruth Helen, Delattre, Olivier, Janoueix-Lerosey, Isabelle, Vigny, Marc
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Public Library of Science 2012
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3316580/
https://ncbi.nlm.nih.gov/pubmed/22479414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033581
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