Activated Alk triggers prolonged neurogenesis and Ret upregulation providing a therapeutic target in ALK-mutated neuroblastoma

Activating mutations of the ALK (Anaplastic lymphoma Kinase) gene have been identified in sporadic and familial cases of neuroblastoma, a cancer of early childhood arising from the sympathetic nervous system (SNS). To decipher ALK function in neuroblastoma predisposition and oncogenesis, we have cha...

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Autori principali: Cazes, Alex, Lopez-Delisle, Lucille, Tsarovina, Konstantina, Pierre-Eugène, Cécile, De Preter, Katleen, Peuchmaur, Michel, Nicolas, André, Provost, Claire, Louis-Brennetot, Caroline, Daveau, Romain, Kumps, Candy, Cascone, Ilaria, Schleiermacher, Gudrun, Prignon, Aurélie, Speleman, Frank, Rohrer, Hermann, Delattre, Olivier, Janoueix-Lerosey, Isabelle
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2014
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4058037/
https://ncbi.nlm.nih.gov/pubmed/24811913
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