Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation

Chemically induced skin carcinomas in mice are a paradigm for epithelial neoplasia, where oncogenic ras mutations precede p53 and INK4a/ARF mutations during the progression toward malignancy. To explore the biological basis for these genetic interactions, we studied cellular responses to oncogenic r...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Lin, Athena W., Lowe, Scott W.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2001
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC33157/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11309506/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.091100298
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