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Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation
Chemically induced skin carcinomas in mice are a paradigm for epithelial neoplasia, where oncogenic ras mutations precede p53 and INK4a/ARF mutations during the progression toward malignancy. To explore the biological basis for these genetic interactions, we studied cellular responses to oncogenic r...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The National Academy of Sciences
2001
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC33157/ https://ncbi.nlm.nih.gov/pubmed/11309506 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.091100298 |
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