Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation
Chemically induced skin carcinomas in mice are a paradigm for epithelial neoplasia, where oncogenic ras mutations precede p53 and INK4a/ARF mutations during the progression toward malignancy. To explore the biological basis for these genetic interactions, we studied cellular responses to oncogenic r...
Zapisane w:
| Wydane w: | Proc Natl Acad Sci U S A |
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| Główni autorzy: | , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
National Academy of Sciences
2001
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC33157/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11309506/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.091100298 |
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