Epigenetic Silencing of the Circadian Clock Gene CRY1 is Associated with an Indolent Clinical Course in Chronic Lymphocytic Leukemia

Disruption of circadian rhythm is believed to play a critical role in cancer development. Cryptochrome 1 (CRY1) is a core component of the mammalian circadian clock and we have previously shown its deregulated expression in a subgroup of patients with chronic lymphocytic leukemia (CLL). Using real-t...

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Detalhes bibliográficos
Main Authors: Hanoun, Maher, Eisele, Lewin, Suzuki, Masako, Greally, John M., Hüttmann, Andreas, Aydin, Semra, Scholtysik, René, Klein-Hitpass, Ludger, Dührsen, Ulrich, Dürig, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314606/
https://ncbi.nlm.nih.gov/pubmed/22470559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034347
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