The Arg-293 of Cryptochrome1 is responsible for the allosteric regulation of CLOCK-CRY1 binding in circadian rhythm

Mammalian circadian clocks are driven by transcription/translation feedback loops composed of positive transcriptional activators (BMAL1 and CLOCK) and negative repressors (CRYPTOCHROMEs (CRYs) and PERIODs (PERs)). CRYs, in complex with PERs, bind to the BMAL1/CLOCK complex and repress E-box–driven...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Gul, Seref, Aydin, Cihan, Ozcan, Onur, Gurkan, Berke, Surme, Saliha, Baris, Ibrahim, Kavakli, Ibrahim Halil
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2020
Sujets:
Gene Regulation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7863883/
https://ncbi.nlm.nih.gov/pubmed/33028638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014333
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