A CLOCK-binding small molecule disrupts the interaction between CLOCK and BMAL1 and enhances circadian rhythm amplitude

Proper function of many physiological processes requires a robust circadian clock. Disruptions of the circadian clock can result in metabolic diseases, mood disorders, and accelerated aging. Therefore, identifying small molecules that specifically modulate regulatory core clock proteins may potentia...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Doruk, Yagmur Umay, Yarparvar, Darya, Akyel, Yasemin Kubra, Gul, Seref, Taskin, Ali Cihan, Yilmaz, Fatma, Baris, Ibrahim, Ozturk, Nuri, Türkay, Metin, Ozturk, Narin, Okyar, Alper, Kavakli, Ibrahim Halil
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7076206/
https://ncbi.nlm.nih.gov/pubmed/32019867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011332
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