A CLOCK-binding small molecule disrupts the interaction between CLOCK and BMAL1 and enhances circadian rhythm amplitude

Proper function of many physiological processes requires a robust circadian clock. Disruptions of the circadian clock can result in metabolic diseases, mood disorders, and accelerated aging. Therefore, identifying small molecules that specifically modulate regulatory core clock proteins may potentia...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Doruk, Yagmur Umay, Yarparvar, Darya, Akyel, Yasemin Kubra, Gul, Seref, Taskin, Ali Cihan, Yilmaz, Fatma, Baris, Ibrahim, Ozturk, Nuri, Türkay, Metin, Ozturk, Narin, Okyar, Alper, Kavakli, Ibrahim Halil
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2020
Schlagworte:
Gene Regulation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7076206/
https://ncbi.nlm.nih.gov/pubmed/32019867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011332
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