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Structure Based Discovery of Small Molecules to Regulate the Activity of Human Insulin Degrading Enzyme
BACKGROUND: Insulin-degrading enzyme (IDE) is an allosteric Zn(+2) metalloprotease involved in the degradation of many peptides including amyloid-β, and insulin that play key roles in Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM), respectively. Therefore, the use of therapeutic a...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3280214/ https://ncbi.nlm.nih.gov/pubmed/22355395 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031787 |
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