Structure Based Discovery of Small Molecules to Regulate the Activity of Human Insulin Degrading Enzyme

BACKGROUND: Insulin-degrading enzyme (IDE) is an allosteric Zn(+2) metalloprotease involved in the degradation of many peptides including amyloid-β, and insulin that play key roles in Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM), respectively. Therefore, the use of therapeutic a...

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Sonraí Bibleagrafaíochta
Main Authors: Çakir, Bilal, Dağliyan, Onur, Dağyildiz, Ezgi, Bariş, İbrahim, Kavakli, Ibrahim Halil, Kizilel, Seda, Türkay, Metin
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2012
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280214/
https://ncbi.nlm.nih.gov/pubmed/22355395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031787
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